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KMID : 0378019870300080075
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New Medical Journal
1987 Volume.30 No. 8 p.75 ~ p.80
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The Clinical Trial of Malotilate in Patients with Compensated Liver Cirrhosis
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Abstract
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The clinical efficacy of Malotilate was evaluated in 36 patients with compensated liver cirrhosis. Experimental group was administered with 600 mg of Malotilate orally per day for 12 weeks, and we observed variation of liver functions, the size of the liver and spleen, and untoward side effects.
The results obtained were as follows:
1) After administration with Malotilate, serum GOT and GPT were significantly decreased (P<0.05) and cholinesterase was significantly increased (P<0.05).
2) After administration with Malotilate, there were no significant changes in serum total bilirubin, r-GTP, albumin, alkaline phosphatase, and total cholesterol.
3) After administration with Malotilate, the size of the liver and spleen was decreased in 18 of 26 patients on isotope scan.
4) The side effects of Malotilate were itching (one case), indigestion (one case), epigastric discomfort (one case), and transient hematuria (one case). But these side effects were spontaneously subsided in spite of continued administration of this drug, and there were no evidences of worsened liver function.
The results of this study suggest that Malotilate is effective and safe drug in compensated liver cirrhosis and we hope that long term administration and follow up study will be necessary.
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